Can a Vape Set Off a Fire Alarm? What You Should Know Vape sets off smoke detector on plane So, This Is What Actually Happens If You Smoke Or Vape On A Plane HuffPost UK Life Will Vaping Set Off Hotel Smoke Alarms? Vaping and Smoke Alarms: What Actually Triggers the Sensors Vapesdirect Smoking or vaping is not allowed on any flight to or from the United States. You can carry an e cig in your hand luggage, but you cannot use it in the cabin.